Anterior Crucuate Ligament (a.c.l) Reconstruction In Conjuction with Stem Cells

The anterior cruciate ligament is the ligament which is most frequently seen as a result of a sports injury, deceleration or traffic accidents.

The incidence of this type injury is constantly increasing, due to the participation of more and more people of a younger  age in the professional or amateur sports, and seems to be seen two to eight times more in female  than male  (open pubic symphysis, valgus knee, pronation foot, muscle building , hormonal differences, different anatomy ofcruciate ligaments and femoral notch).

Europeans and Americans have a higher incidence of such injuries in relation to African-Americans, Asians and Spanish-speaking.

Basketball, hockey , football players and gymnasts are suffering more often  from such a sport related injury, followed  in frequency by  skiers and volleyball players.

In the US we have about 250,000 injuries (1 in 1,750) every year ,in individuals aged 15-45 years, while the corresponding figure in our country exceeds to about 4,000 per year. Only in 30% of cases the injury is by direct contact with an opponent.

The total cost for treatment of injuries to the cruciate ligament is estimated to be about 2-3 billion dollars per year, suggesting the enormous socio-economic cost of these injuries.

Over 540 counted reconstruction techniques for an ACL injury are described in the literature, but the big problem among sport scientists  is the recovery time, which ranges from 6 to 12 months, depending on the athlete’s participating  sport.

The grafts used to repair the rupture of the cruciate ligament (autologous or allografts ) are in fact “dead”  grafts at the time of implantation. They function more like biological scaffolds, showing initial stability, but they need cell integration- revascularization, otherwise they can fail and re-rupture can be occur.

It seems that this time for graft revascularization cruciate ligament is estimated to be between 4-5 months, post-operatively.

New revolutionary surgical technique using autologous adult bone marrow stem cells comes to change international standards and promises to reduce recovery time and revascularization of the grafts in almost half of a time that a graft needs to be revascularized  itself.

The method has many advantages for the surgeon

  • rapid regeneration of the implant and faster knee stability
  • dramatically reduces failure (re-rupture or failure of the new graft)
  • significantly reduces the risk of contamination through secretion of LL-37 peptide, which is the most well-known in the literature potent antimicrobial agent
  • reduces postoperative stiffness
  • reduces post-operative swelling and pain
  • rapidly increases the joint range of motion

The total cost for treatment of injuries to the cruciate ligament is estimated to be about 2-3 billion dollars per year, suggesting the enormous socio-economic cost of these injuries.

Over 540 counted reconstruction techniques for an ACL injury are described in the literature, but the big problem among sport scientists  is the recovery time, which ranges from 6 to 12 months, depending on the athlete’s participating  sport.

The grafts used to repair the rupture of the cruciate ligament (autologous or allografts ) are in fact “dead”  grafts at the time of implantation. They function more like biological scaffolds, showing initial stability, but they need cell integration- revascularization, otherwise they can fail and re-rupture can be occur. It seems that this time for graft revascularization cruciate ligament is estimated to be between 4-5 months, post-operatively.

New revolutionary surgical technique using autologous adult bone marrow stem cells comes to change international standards and promises to reduce recovery time and revascularization of the grafts in almost half of a time that a graft needs to be revascularized  itself.

The method has many advantages for the surgeon

  • rapid regeneration of the implant and faster knee stability
  • dramatically reduces failure (re-rupture or failure of the new graft)
  • significantly reduces the risk of contamination through secretion of LL-37 peptide, which is the most well-known in the literature potent antimicrobial agent
  • reduces postoperative stiffness
  • reduces post-operative swelling and pain
  • rapidly increases the joint range of motion

The use of stem cells to regenerate the ACL is not a simple process. It requires experienced and specialized medical team, specific rehabilitation protocols and of course proper stem cell isolation.

Drainage use is prohibited and specific hemostasis protocols are required. The method requires also specific recovery protocol which begins a few hours post-operatively  and ends with the proper rehabilitation. Stem cell application in a special manner is performed again 2 weeks post-operatively.

MRI scan six weeks postoperatively, is needed in order to show graft incorporation and re-vascularization.

Dr. Alevrogiannis can assess your condition and condition, either in his office or at the Metropolitan General.

The use of stem cells to regenerate the ACL is not a simple process. It requires experienced and specialized medical team, specific rehabilitation protocols and of course proper stem cell isolation. Drainage use is prohibited and specific hemostasis protocols are required. The method requires also specific recovery protocol which begins a few hours post-operatively  and ends with the proper rehabilitation. Stem cell application in a special manner is performed again 2 weeks post-operatively. MRI scan six weeks postoperatively, is needed in order to show graft incorporation and re-vascularization.

Dr. Alevrogiannis can assess your condition and condition, either in his office or at the Metropolitan General.